hcn.health, as data

Two prospective cohorts found that metabolically unhealthy adults generally had higher dementia risk estimates regardless of obesity status. Metabolically healthy obesity was not associated with increased dementia risk in primary analyses, though findings varied across sensitivity analyses.Endocrinology, Diabetes, MetabolismALZHEIMER'S/DEMENTIA CHRONIC DISEASE MANAGEMENT COHORT STUDY EPIDEMIOLOGY METABOLIC HEALTH OBESITY/WEIGHT MANAGEMENT RISK FACTORS#### Distinct Roles of the Human Cuneiform and Pedunculopontine Nuclei in Gait and Freezing of GaitRecordings from four Parkinson’s disease patients linked cuneiform and pedunculopontine nuclei activity to distinct phases of gait initiation. Freezing episodes were preceded by disrupted mesencephalic timing, though clinical translation remains early.BIOMARKERS CLINICAL STUDY FREEZING OF GAIT (FOG) MEDICAL DEVICES MOTOR FUNCTION MOVEMENT DISORDERS NEUROMODULATION PARKINSON'S DISEASE (PD)#### Responsive Stimulation of the Thalamus for Idiopathic Generalized Epilepsy: Results of the Randomized Controlled NAUTILUS Trial Through 18 MonthsThe NAUTILUS trial met its primary safety endpoint for responsive centromedian thalamic stimulation in drug-resistant idiopathic generalized epilepsy. The prespecified primary effectiveness endpoint was not significant, while post hoc and 18-month outcomes showed sustained seizure reductions.ANTISEIZURE MEDICATIONS CLINICAL STUDY EPILEPSY/SEIZURES MEDICAL DEVICES NEUROMODULATION PATIENT SAFETY QUALITY OF LIFE#### Bidirectional Link Found Between TBI and Neurologic DiseaseA large Veterans Health Administration study found that older adults with traumatic brain injury had elevated rates of several neurologic disorders both before and after injury. The findings support a bidirectional association between TBI and neurologic disease but do not establish causality.