science.org, as data

science](https://science.org/journal/science)### An autoinflammatory CDC42 variant nucleates pyrinA pathogenic CDC42 M45L variant strengthens binding to pyrin B30.2, triggering inflammasome activation and autoinflammatory disease.### Nature-inspired mesh captures microplasticsScience Translational Medicine5 Aug 2026### Fecal microbiome transplant for food allergyScience Signaling4 Aug 2026### Microglia on clean-up duty after strokeVisa stress clouds my life as a scientist and parent### Calcium tunes snail mucus–based materials to multiple functionsSenate votes to block rule giving White House more control over researchPlanned satellite megaconstellations could generate runaway space debrisGlobal warming is coming for the countrysideDNA reveals the hidden past of North America’s bison—and keys to their futureTau protein can sneak into brain cells’ energy factories—and wreak havocNIH Director Bhattacharya kills more health disparities grantsFew have placed sovereignty as squarely at the center of their AI strategy as India—and few are as well positioned to achieve it. * **Editorial** * 6 August 2026 * Akash Kapur and Arvind Narayanan#### Advertisement## First Release### Recovering signatures of archaic hominin introgression using ancestral recombination graphs### Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts### Programmable design of synthetic plant immune receptors for pathogen protein recognition### Helium escaping from the atmosphere of a nearby rocky exoplanet orbiting in a habitable zone### A cinnamyl alcohol dehydrogenase–like scaffold organizes monoterpenoid indole alkaloid biosynthesis### De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging### Preferred synthesis of armchair transition metal dichalcogenide nanotubes### Autonomous biomedical research with an artificial intelligence agent